After suffering partial paralysis while searching for a long-lost love, lottery winner Cyrus Harry (guest star Logue) is brought to Princeton Plainsboro for treatment by House and the team. Cuddy’s mother (guest star Bergen) threatens to sue the hospital for malpractice, jeopardizing both Cuddy and House’s medical licenses. Chase and Foreman make a bet that tests each one in different ways.
Masters faces a career crossroads on her last day as a medical student and struggles with the choice to continue on the path to become a surgeon or to accept the rare opportunity to join House’s team officially. Meanwhile, the team treats a 16-year-old girl who inexplicably collapsed days before embarking on an ambitious sailing tour around the globe. Despite the patient's life-changing diagnosis, the patient's family insists on getting her back on the seas in time for her potentially record-breaking launch. But to the team's surprise, including House, Masters makes a bold decision regarding the patient’s treatment.