A CEO (guest star Michael Nouri) falls mysteriously ill just days before he signs a contract that would relocate his company’s entire labor force to China. House (Hugh Laurie) attempts to make an underhanded business transaction with his wealthy patient, but when his condition worsens, the team must work around the clock to save his life. Meanwhile, Park (Charlyne Yi) prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman (Omar Epps), and Adams’ (Odette Annable) outlook on her patient’s business venture reveals her deeper feelings about loyalty.
House and the team battle to save a successful, independent blind man (guest star Jordan) who is struck down by a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House's mother (guest star Baker) unexpectedly arrives at Princeton Plainsboro to inform him of her new beau (guest star Connolly). Cast: Hugh Laurie as Dr. Gregory House; Robert Sean Leonard as Dr. James Wilson; Omar Epps as Dr. Eric Foreman; Jesse Spencer as Dr. Robert Chase; Peter Jacobson as Dr. Chris Taub; Odette Annable as Dr. Jessica Adams; Charlyne Yi as Dr. Chi Park; Karolina Wydra as Dominika Patrova; Michael B. Jordan as Will; Margo Harshman as Melissa; Diane Baker as Blythe House; Billy Connolly as Thomas; John Eric Montana as Sam; Ryan Driscoll as Stacy; Bobbin Bergstrom as Nurse