When young wife Elyse falls ill with a rare disease she can't possibly have, Dr. Cameron is very interested in the case - so much so that her interest convinces House to take the case, and the team struggles to save her and appease her very attentive husband, Ed (guest star Dominic Purcell). After Dr. House and Dr. Wilson treat a woman at the clinic with new breast implants, the idea that House's new patient Elyse may have breast cancer is raised as a possible diagnosis. But that diagnosis fails to be the answer when Elyse lapses into a coma after starting treatment. House starts to suspect Elyse has contracted a rare sexually transmitted disease, but when Ed and Elyse are questioned individually, they each deny having an affair. To save their patient's life, the team has to acknowledge that House is right: everybody lies. Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase.
When it appears that Lucy Palermo, a schizophrenic mom with deadly deep vein thrombosis, is lying about her alcohol intake, Dr. House is the lone voice of reason. Under the scrutiny of her hyper-vigilant teenage son, House takes Lucy off all her medication and secretly sends Foreman and Chase to search her apartment for clues. An anonymous call to Social Services makes House question whether Lucy is really schizophrenic, and causes Lucy's son, Lucas, to blame Dr. House for making the call. Wading through Lucy's altered reality to get to the truth and save her life, House discovers it isn't mom who's keeping the secrets and reality isn't always what it seems. Cast: Hugh Laurie as Dr. Gregory House, Lisa Edelstein as Dr. Lisa Cuddy, Omar Epps as Dr. Eric Foreman, Robert Sean Leonard as Dr. James Wilson, Jennifer Morrison as Dr. Allison Cameron, Jesse Spencer as Dr. Robert Chase.
When a nun comes into the clinic with swollen arms, rash and bleeding in her palms, Dr. House's diagnosis is a bad allergy, not stigmata. However, when he gives her a shot of medication, she has a heart attack, and whether he gave her the correct amount of medicine comes into question. As the the nun's case unfolds, the team has to deal with questions regarding their own calling, faith and whether or not they can trust the direction in which their mentor is leading them. Cast: Hugh Laurie as Dr. Gregory House, Lisa Edelstein as Dr. Lisa Cuddy, Omar Epps as Dr. Eric Foreman, Robert Sean Leonard as Dr. James Wilson, Jennifer Morrison as Dr. Allison Cameron, Jesse Spencer as Dr. Robert Chase.