Legendary jazz musician John Henry Giles (guest star Henry Lennix) checks into Princeton Plainsboro Teaching Hospital believing he's dying from ALS and signs a Do Not Resuscitate request in order to avoid a slow death. House disagrees with the diagnosis and goes against everyone's wishes when he violates the DNR to save Giles' life. The decision lands House in court, drives Foreman to consider taking another job and results in Giles' paralysis worsening. But when the patient inexplicably starts getting better, the team has to figure out the mystery in reverse and find out why his condition is improving.
Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase.