After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl's palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control's Dr. Dave Broda (guest star Baker) institutes a lockdown on the hospital and suspends House's team's ability to diagnose, Masters (guest star Tamblyn) grows suspicious of Broda's motives and becomes convinced that the patient is suffering from a different disease. The girl's father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in jeopardy. Meanwhile, Wilson and Sam (guest star Watros) comfort a 6-year-old chemotherapy patient who prompts them to examine their relationship.
Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Robert Sean Leonard as Dr. James Wilson; Omar Epps as Dr. Eric Foreman; Jesse Spencer as Dr. Robert Chase; Olivia Wilde as Thirteen/Dr. Remy Hadley; Peter Jacobson as Dr. Chris Taub